Fundamental differences in the equilibrium considerations for siRNA and antisense oligodeoxynucleotide design
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چکیده
منابع مشابه
Fundamental differences in the equilibrium considerations for siRNA and antisense oligodeoxynucleotide design
Both siRNA and antisense oligodeoxynucleotides (ODNs) inhibit the expression of a complementary gene. In this study, fundamental differences in the considerations for RNA interference and antisense ODNs are reported. In siRNA and antisense ODN databases, positive correlations are observed between the cost to open the mRNA target self-structure and the stability of the duplex to be formed, meani...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2008
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkn266